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GDP-fucose protein O-fucosyltransferase 2
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GDP-fucose protein O-fucosyltransferase 2 : ウィキペディア英語版
GDP-fucose protein O-fucosyltransferase 2

GDP-fucose protein ''O''-fucosyltransferase 2 (POFUT2) is an enzyme responsible for adding fucose sugars in ''O'' linkage to serine or threonine residues in Thrombospondin repeats.〔(GDP-fucose protein O-fucosyltransferase 2, The Universal Protein Resource )〕 The protein is an inverting glycosyltransferase, which means that the enzyme uses GDP-β-L-fucose as a donor substrate and transfers the fucose in ''O'' linkage to the protein producing fucose-α-''O''-serine/threonine.
Almost all glycosyltransferases reside in the Golgi apparatus. However, POFUT2 as well as the related enzyme POFUT1 have recently been shown to reside in the endoplasmic reticulum.
==References==


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